Valliscor offers commercial solutions for our customers’ organofluorine needs. These products include bromofluoromethane (BFM, CAS # 373-52-4),
fluoroiodomethane (FIM, CAS # 373-53-5), 4,4,5,5,5-pentafluoro-1-pentanol (PFP, CAS # 148043-73-6), dibromofluoromethane (DBFM, CAS # 1868-53-7) and hexafluoro-1,3-butadiene (C4F6, CAS # 685-63-2). Valliscor also produces select fluorine-containing heterocycles such as 2-chloro-4-fluoropyridine (CFP, CAS # 34941-91-8). For ozone depleting substance (ODS), we are well-versed in addressing the regulatory hurdles regarding the Montreal Protocol. If you do not see the exact solution you are looking for, we welcome specific inquiries. Contact us at us via email at info@valliscor.com or by phone at +1 541-286-5082.
Supporting API Supply Chains. We have considerable experience in delivering reoccurring, commercial quantities of key starting materials into on-the-market API supply chains. For example, we are the global dominant manufacturer of bromofluoromethane for use in the manufacture of fluticasone propionate and fluticasone furoate. In addition, we routinely supply 4,4,5,5,5-pentafluoro-1-pentanol for use in the manufacture of fulvestrant.
(Catalog # VCBFM, CAS # 373-52-4, bp 20 °C) reagent for fluoromethylation, important building block in the synthesis of fluticasone propionate & fluticasone furoate (J. Med. Chem. 1994, 37, 3717-3729
), available in high purity (>99.9%). [Bromofluoromethane SDS/MSDS]
For more information, visit our dedicated bromofluoromethane page.
(Catalog # VCPFP, CAS # 148043-73-6, bp 133 °C). Important building block used in the commercial manufacture of API fulvestrant (Org. Proc. Res. Dev. 2010, 14 (3), 544-552
). [4,4,5,5,5-pentafluoro-1-pentanol SDS/MSDS]
For more information, visit our dedicated 4,4,5,5,5-pentafluoro-1-pentanol (PFP) page.
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(Catalog # VCHFBD, CAS #685-63-2, bp 6 °C). 1,1,2,3,4,4-Hexafluoro-1,3-butadiene (C4F6) is an important etchant gas in the semiconductor industry with a ZERO global warming potential (GWP). C4F6 is used in the manufacture of memory (e.g. DRAM, NAND, 3D NAND) chips and other high aspect ratio (HAR) applications. [hexafluoro-1,3-butadiene SDS/MSDS]
For more information, visit our dedicated hexafluoro-1,3-butadiene (C4F6) page.
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(Catalog # VCFIM, CAS # 373-53-5, bp 53 °C) reagent for fluoromethylation, non-ozone depleting alternative to BFM for fluoromethylation of steroids (U.S., 4996335, 26 Feb 1991) including fluticasone propionate (See J. Med. Chem. 1994, 37, 3717-3729
). Available on commerical scale. [Fluoroiodomethane SDS/MSDS]
(Catalog # VCDFIM, CAS # 1493-03-4, bp 22 °C) is an electrophilic, non-ozone depleting difluoromethylation reagent. Available on commercial scale. [Difluoroiodomethane SDS/MSDS]
(Catalog # VCTBFM, CAS # 353-54-8, bp 106-107 °C) is a functionalized bromofluorocarbon.
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(Catalog # VCDBFM, CAS # 1868-53-7, bp 65 °C) reagent for a wide variety of functionalization - from cyclopropanation to alkylation to dipolar cycloadditions. In many of these transformations, the resultant products contain fluorine. Available on commercial scale. [Dibromofluoromethane SDS/MSDS]
For more information, visit our dedicated dibromofluoromethane page.
(Catalog # VCDBDFM, CAS # 75-61-6, bp 23 °C) is a bifunctional difluoromethylation reagent.
[Dibromodifluoromethane MSDS/SDS]
For more information, visit our dedicated dibromodifluoromethane page.
(Catalog # VCBDFM, CAS # 1511-62-2, bp -14.6 °C) reagent for difluoromethylation including in the production of pantoprazole as a replacement for R-22 (CF2CHCl). MacMillan and co-workers employed BDFM in metallaphotoredox difluoromethylation of aryl bromides (
Angew. Chem. Int. Ed. 2018, 57, 12543-12548
).
(Catalog # VCBDFE, CAS # 420-43-9, bp 15 °C) building block for difluoroethylation. Zhang and co-workers reported the use of DBFE in Iron-promoted cross couplings (
Angew. Chem. Int. Ed. 2018, 57, 6921-6925
)
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(Catalog # VCBFE, CAS # 2311-13-9, bp 37 °C) building block for fluoroethylation
(PCT Int. Appl., 2002040459, 23 May 2002).
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(Catalog # VCBTFE, CAS # 354-07-4, bp 14 °C) building block for tetrafluoroethylation
(PCT Int. Appl., 2010125985, 04 Nov 2010).
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(Catalog # VCBPFE, CAS # 354-55-2, bp -21 °C). Intermediate used by Saltigo researchers in the production of the fluorinated alcohol intermediate 4,4,5,5,5-pentafluoro-1-pentanol (PFP) used in the synthesis of the API fulvestrant (EP2196449A1).
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2-Chloro-4-fluoropyridine (CFP, Catalog # VCCFP, CAS # 34941-91-8 , bp 140 °C) is common intermediate used in the synthesis of biological active compounds. [Chlorofluoropyridine SDS/MSDS]
For more information, visit our dedicated 2-chloro-4-fluoropyridine page.
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