Dibromodifluoromethane (DBDFM) 

Valliscor Capabilities for ​Dibromodifluoromethane (DBDFM) 

Dibromodifluoromethane (DBDFM) is a useful tool for a wide variety of functionalization – from cyclopropanation to alkylation to the LCD and OLED markets. In many of these transformations, the resultant products contain fluorine. Using proprietary technology, Valliscor manufactures kilogram to commercial scale of high purity DBDFM (>98% pure) for the pharmaceutical industry in its Corvallis, Oregon production facility. To find out more information on our offerings, please contact us at info@valliscor.com.

Alternate Names:
 DBDFM, difluorodibromomethane, Halon 1202, Fluorocarbon 12-B2, FC 12-B2, R 12B2, UN 1941, Freon 12B2
Catalog #: VCDBDFM
CAS #: 75-61-6
Molecular Weight: 209.82 g/mol
Density: 2.29 g/mL
Boiling Point: 23°C
19F NMR Spectra (CDCl3): 7.00 (s) ppm
Wikipedia Link: https://en.wikipedia.org/wiki/DibromodifluoromethaneMaterial Safety Data Sheet (MSDS) / Safety Data Sheet (SDS): [DOWNLOAD]
Downloadable Flyer on Valliscor’s Dibromodifluoromethane (DBDFM) Capabilities: [DOWNLOAD]

Olefination of Carbonyls

Numerous examples have been reported for the use of dibromodifluoromethane (DBDFM) for the difluoromethylation of aldehydes using both Zn as the reducing agent (Eq. 1, J. Fluorine Chem. 2012, 143, 177-198 ) as well as HMPT itself (Eq. 2, J. Fluorine Chem. 2015, 179, 106-115 ). Numerous other examples of this type of transformation have been reported (e.g., J. Fluorine Chem. 2006, 127, 610-619 ;  Org. Lett. 2015, 17, 1126-1129 ).

These products derived from dibromodifluoromethane (DBDFM) have been in carbohydrate synthesis where the resultant difluorovinyl moiety is used in incorporate a difluromethyl linker (Eq. 3, J. Am. Chem. Soc. 2007, 129, 15420-15421 ) and nucleosides where the resultant difluorovinyl moiety is hydrogenated to access a difluoromethyl group (Eq. 4, J. Org. Chem. 200570,3826-3837 ). Additional applications include as carbonyl mimics (J. Am. Chem. Soc. 2003, 125, 6348-6349 ) and sugar mimesis (Angew. Chem. Int. Ed. 2004, 43, 6680-6683 ).

Product Inquiry

  • This field is for validation purposes and should be left unchanged.