Valliscor Fluoroalkylation Reagents

Valliscor offers a platform of reagents for our customers’ fluoroalkylation needs including bromofluoromethane (BFM, CAS # 373-52-4), fluoroiodomethane (FIM, CAS # 373-53-5), dibromofluoromethane (DBFM, CAS # 1868-53-7) and dibromodifluoromethane (DBDFM, CAS #  75-61-6).  We are well-versed in addressing the regulatory hurdles regarding ozone-depleting substances and the Montreal Protocol. We have considerable experience in supplying high purity bromofluoromethane (>99.9%) for use in the manufacture of fluticasone propionate.  In addition to the products listed below, we welcome specific inquiries. Contact us for custom fluoroalkylation reagents to meet your specifications. Please check out our recent flyer summarizing our key products.

Bromofluoromethane (BFM)

For more information, visit our dedicated bromofluoromethane page. (Catalog # VCBFM, CAS # 373-52-4, bp 19°C) reagent for fluoromethylation, important building block in the synthesis of fluticasone propionate & fluticasone furoate (J. Med. Chem. 199437, 3717-3729), available in high purity (>99.9%). [Bromofluoromethane SDS/MSDS]

Fluoroiodomethane (FIM)

(Catalog # VCFIM, CAS # 373-53-5, bp 53°C) reagent for fluoromethylation, non-ozone depleting alternative to BFM for fluoromethylation of steroids (U.S., 4996335, 26 Feb 1991) including fluticasone propionate (J. Med. Chem. 1994, 37, 3717-3729). [Fluoroiodomethane SDS/MSDS]

Bromodifluoromethane (BDFM)

(Catalog # VCBDFM, CAS # 1511-62-2, bp -14.6 °C) reagent for difluoromethylation including in the production of pantoprazole as a replacement for R-22 (CF2CHCl).

Dibromofluoromethane (DBFM)

For more information, visit our dedicated dibromofluoromethane page. (Catalog # VCDBFM, CAS # 1868-53-7, bp 65 °C) reagent for a wide variety of functionalization - from cyclopropanation to alkylation to dipolar cycloadditions. In many of these transformations, the resultant products contain fluorine. [Dibromofluoromethane SDS/MSDS]

Difluoroidomethane (DFIM)

(Catalog # VCDFIM, CAS # 1493-03-4, bp 22 °C) is an electrophilic difluoromethylation reagent.

Dibromodifluoromethane (DBDFM)

For more information, visit our dedicated dibromodifluoromethane page. (Catalog # VCDBDFM, CAS # 75-61-6, bp 23 °C) is a bifunctional difluoromethylation reagent. [Dibromodifluoromethane MSDS/SDS]

Tribromofluoromethane (TBFM)

(Catalog # VCTBFM, CAS # 353-54-8, bp 106-107 °C) is a functionalized bromofluorocarbon.

1-Bromo-1-fluoroethane (BFE)

(Catalog # VCBFE, CAS # 2311-13-9, bp 37 °C) building block for fluoroethylation (PCT Int. Appl., 2002040459, 23 May 2002).

1-Bromo-1,1-difluoroethane (BDFE)

(Catalog # VCBDFE, CAS # 420-43-9, bp 15 °C) building block for difluoroethylation.

1-Bromo-1,1,2,2-tetrafluoroethane (BTFE)

(Catalog # VCBTFE, CAS # 354-07-4, bp 14 °C) building block for tetrafluoroethylation (PCT Int. Appl., 2010125985, 04 Nov 2010).

2-Bromo-1,1,1,3,3,3-hexafluoropropane (B6FP)

(Catalog # VCB6FP, CAS # 2252-79-1, bp 36 °C) synthon for accessing fluorinated propanes (U.S. Pat. Appl. Publ., 20080085237, 10 Apr 2008).

2-Bromo-1,1,1,2,3,3,3-heptafluoropropane (B7FP)

(Catalog # VCB7FP, CAS # 422-77-5, bp 19 °C) synthon for accessing polyfluorinated propanes (PCT Int. Appl., 2012077221, 14 Jun 2012). Precursor to C3F7TMS (iso-propyl Ruppert’s reagent).